Effect of Recombinant Human Erythropoietin on Reticulocyte Age in Hemodialysis Patients

Does recombinant human erythropoietin affect plasma lipids in hemodialysis patients?

Prof. Dr. Kuddusi Cengiz, Ondokuz Mayis University School of Medicine, Department of Nephrology, TR-55139 Samsun (Turkey) Dear Sir, The correction of anemia in hemodialysis patients with human recombinant erythropoietin increases appetite, anabolic effects, and improves physical, psychological activities and endocrine functions. As the sense of well-being improves, the patients increase food in...

Subcutaneous versus intravenous recombinant human erythropoietin administration in hemodialysis patients.

Impact of inflammation on anemia of hemodialysis patients who were under treatment of recombinant human erythropoietin

The aim of this study was to investigate the association between serum C-reactive protein (CRP) as the marker of inflammation with serum ferritin level and its role in the severity of anemia of hemodialysis (HD) patients. A cross-sectional study was conducted on a group of stable hemodialysis patients. There were 36 patients overall, 25 of which were non-diabetic and 11 were diabetic mean patie...

The effect of recombinant human erythropoietin (rHuEpo) on blood cells of adult and immature rats

Human recombinant erythropoietin is a synthetic hormone for treatment of some kinds of anemia. In this study, the effect of this hormone was investigated on blood cell changes in adult and immature rats. For this purpose, the hormone was administered at doses of 50, 100, and 200 IU/Kg (s.c.) twice a week for a period of 6 weeks. Then, the number of red blood cells (RBC), subtypes of white blood...

Effects of Recombinant Human Erythropoietin (rHuEpo) on the Blood Cells and Hematopoiesis in Spleen of Rats

Recombinant human erythropoietin is a glycoprotein hormone that stimulates erythropoiesis. In clonogenic assays of hematopoietic progenitors, high concen-trations of erythropoietin (Epo) increase CFU-E and diminish the number of granulocytes formed per culture plate. Fetal progenitors are more sensitive to these effects of Epo than progenitors from adults. We administered doses 50, 100, 200 IU/...